14th Annual University of Pennsylvania Conference on Statistical Issues in Clinical Trials / Subgroup Analysis in Clinical Trials:  Opportunities and Challenges

Sunday, June 12, 2022 - Monday, June 13, 2022
4:00 am - 3:59 am
06/12/22 - 4:00am to 06/13/22 - 3:59am
Add to Calendar

Tuesday, April 12, 2022

8:30am to 4:30pm (EDT)

Virtually via BlueJeans


Please note:
  • Once registered, each registrant will receive a unique URL to join the conference
  • The URL is NOT to be transferred or shared with non-registrants in any way


  • PENN faculty and students: $0
  • Academic, Government, Non-Profit:  $60
  • Industry:  $85
  • Non-PENN students:  $25



David Kent, MD (Tufts University)
Overview: Overall average treatment effects and one-variable-at-a-time subgroup analysis:

The Scylla and Charybdis of Evidence Based Medicine
Ellis Unger, MD (Consultant)

An "unofficial" US Regulatory Perspective

Tom Fleming, PhD (University of Washington)

Pitfalls of subgroup analysis

Lisa McShane, PhD (NCI) 

Finding the subgroup of patients who benefit from a novel therapy: no time for a game of

hide and seek


Noah Simon, PhD (University of Washington)

Adaptive Enrichment Trials: Identifying the 'right' subgroup

Anastasia Ivanova, PhD (UNC)

Antimicrobial prophylaxis for vesicoureteral reflux: which children benefit the most?

Ilya Lipkovich, PhD (Eli Lilly)

Comparison of recent approaches for subgroup identification from clinical and observational data

Patrick Schnell, PhD (Ohio State)

Multiplicity considerations for analyses of non-exchangeable subgroups


Mark Rothmann (FDA)

Kosuke Imai (Harvard)

Kit Roes (European Regulatory Perspective)

Michael Rosenblum (Johns Hopkins)

Janet Wittes (Statistics Collaborative, Inc.)


  • To view or download presentation SLIDE SETS, please click on the speaker topic. [Available after the conference]
  • Short biographies for each speaker/panelist are available by clicking on their names above. 


American Statistical Association - 2022 Annual Meeting Information   

Society for Clinical Trials - 2022 Annual Meeting Information

National Institute of Statistical Sciences - 8th Workshop on Biostatistics and Bioinformatics, 2022  



For additional information, contact:
Janine Pritchard
Phone: 215-573-4045 | Email: jpritcha@pennmedicine.upenn.edu