Christina Hao Wang Brotman, MD, MSCE

Dr. Brotman is a clinical nephrologist and epidemiologist whose research focuses on advanced hemodynamic monitoring and dialysis techniques for acute kidney injury and chronic kidney disease. She has a broad background in biomedical engineering and epidemiology, with specific training in hierarchical modeling of longitudinal data and incorporation of advanced technology into clinical application. She has worked on various translational projects, including mathematical models for tumor growth, functional imaging, alternative serum biomarkers to guide clinical diagnostic and treatment decisions, and use of machine learning algorithms to assess the risk of acute kidney injury. She developed a novel method to quantify a semi-instantaneous rate of vascular refilling that could be monitored continuously throughout hemodialysis and studied its association with circulatory instability during hemodialysis treatments. This work has laid the foundation for a line of inquiry in the use of advanced monitoring techniques to improve the precision and tolerance of fluid removal during hemodialysis. She is currently studying the acute impacts of hemodialysis on various areas of systemic and local perfusion, including changes in blood pressure, plasma refill, and cardiac and cerebral perfusion and function. Her work has been funded by the National Institute of Health (NIH) and Industry-sponsored grants. She also teaches various topics related to nephrology and epidemiology to medical students, residents, and fellows, and she serves as a research mentor to medicine residents and fellows in the Perelman School of Medicine’s nephrology division.