Title: Study Efficacy and Safety of COVID-19 Vaccines using Modern Statistical MethodsAbstract: In this talk, I will present my current research on studying effectiveness and safety of COVID-19 vaccines. In the efficacy studies, we applied the state-of-art statistical techniques to compare BNT162b2, mRNA-1273 and Ad26.COV2.S vaccines against the Delta variant in a large cohort of patients in the Michigan Medicine healthcare system. We also evaluated their effectiveness among individuals who take immunosuppressants.