Funding: Agency for Healthcare Research and Quality
Investigator: Mukhopadhyay, SM

The primary objective of the VRP study is to reduce unnecessary vancomycin use in preterm infants by implementing/re-enforcing VRP across multiple NICUs. Additional objectives of the study are to determine the effect of external facilitation on the fidelity of VRP use and to identify barriers and facilitators to implementation of the VRP across NICUs.

This project started in April 2024. The CRCU supports the study with project management and data management services.

Funding: NIDDK
Investigator: Lewis, J

The URBI study is a multicenter parallel group clinical trial. The primary objective is to determine if high-definition white light colonoscopy (HDWLC) using a limited biopsy strategy is non-inferior to HDWLC with a random 4x10cm biopsy strategy to detect dysplasia or sessile serrated adenoma (SSA) in patients with inflammatory bowel disease (IBD). Additional objectives of the study are to determine if HDWLC with a limited biopsy strategy is superior to HDWLC with a random 4x10cm biopsy strategy to detect one or more dysplastic or SSA lesion in patients with IBD, determine whether the number of targeted biopsies differs based on the number of random biopsies obtained and to define the molecular characteristics of the progression of colitis-associated dysplasia.

The URBI study started in July 2024. The CRCU supports the study with project management and data management services.

Clinical trials.gov NCT06560021

Funding:  Patient-Centered Outcomes Research Institute (PCORI)
Investigator:  Neuman, MD

Implementation and Evaluation of a Strategy to Improve Pre-Anesthesia Care Discussions - My Anesthesia Choice (MAC) is an implementation study to improve pre-anesthesia care discussions between care providers and patients who are undergoing hip replacement surgery.  The objective of this research study is to assess the implementation process for and the effectiveness of a quality improvement (QI) strategy to increase shared decision-making around anesthesia options for hip fracture surgery at 6 US hospitals. The QI strategy is to be facilitated by a clinician-administered 1-page bedside conversation aid designed to improve the quality of physician-patient communication.