This course focuses on the application of decision analysis and economic analysis to clinical and policy research. The course begins with material about the selection, use, and analysis of diagnostic tests using two by two tables, likelihood ratios, and ROC curves. The course continues with the introduction of more general tools for decision analysis, including decision trees and other mathematical models. Special emphasis is placed on the assessment and use of utilities in these models. A major focus of the course is the application of economic principles to the evaluation of health outcomes. During seminars, students will carry out practical exercises that include problem solving, critically analyzing published articles, and learning to use computer software that facilitates decision and economic analyses.