Jeffrey S Barrett, PhD
My research is focused on investigating sources of variation in pharmacokinetics and pharmacodynamics applying clinical pharmacologic investigation coupled with modeling and simulation strategies to pursue rational dosing guidance. My group develops pharmacometric approaches to advance PK/PD, medical informatics and disease progression modeling. We have also integrated model-based decision support systems with hospital electronic medical records and pioneered the pediatric knowledgebase development program for the past 6 years. My group is actively involved with creating disease progression models for spinal muscular atrophy (SMA) and pancreatic cancer and his team is developing model-based development approaches for Traditional Chinese Medicine (TCM) and gene therapy.
Cancer epidemiology, complementary/alternative medicine, medical informatics, patient-oriented research, pediatrics, pharmacoepidemiology, veterinary epidemiology
Bayesian modeling,; clinical trials; meta-analysis; repeated measures; survival analysis; time series; Bayesian networks; nonlinear, mixed-effect modeling