Featured Research

brain scans next to charts of brainwaves

Despite substantial criticism, polygraphy remains the only biological method of lie detection in practical use today. The authors sought to find out which would more accurately detect concealed information—polygraphy or functional magnetic resonance imaging.

Daniel D. Langleben, MD; Jonathan G. Hakun, PhD; David Seelig, VMD; An-Li Wang, PhDa; Kosha Ruparel, MS; Warren B. Bilker, PhD; and Ruben C. Gur, PhD

Doctor talking to man holding baby

Depression is highly prevalent among young adults of child-rearing age. The authors investigated whether it would be feasible and acceptable to screen for parental depression in urban pediatric practices—and they identified valuable information for practitioners and policymakers.

James P. Guevara, MD, MPH, Marsha Gerdes, PhD, Brooke Rothman, MSSP, Victor Igbokidi, MD, Susan Doughterty, PhD, Russell Localio, PhD, and Rhonda C. Boyd, PhD

hands breaking cigarette in half

Financial incentives to help people quit smoking are at least as successful as pharmacotherapies, and incentives are being widely adopted in workplace wellness programs. However we need more information about which types of smokers respond best to which types of incentive programs.

Scott D. Halpern, Benjamin French, Dylan S. Small, Kathryn Saulsgiver, Michael O. Harhay, Janet Audrain-McGovern, George Loewenstein, David A. Asch and Kevin G. Volpp

Cartoons of several students with bubbles around their heads indicating mental fog

Calm minds, active bodies: Via a new strategy that helps physicians monitor their young concussion patients in real time, a team from the Perelman School of Medicine and The Children’s Hospital of Philadelphia found new insights that may change recommendations for longer-term treatment.

Douglas J. Wiebe, PhD; Michael L. Nance, MD; Eileen Houseknecht, RN; et al

Mom and child with doctor looking on

Most children who are eligible for early-intervention programs don't participate. The authors devised a novel program to help patients navigate the necessary steps. Would it be feasible—and could it increase these referrals among a diverse group of at-risk children?

James P. Guevara, MD, MPH; Brooke Rothman, Elizabeth Brooks, Marsha Gerdes, Fayetta McMillon-Jones, Katherine Yun

nurse talking to patient in hospital bed

Chimeric antigen receptor (CAR)-modified T cells with anti-CD19 specificity offer a highly effective, novel immune therapy for patients with relapsed/refractory acute lymphoblastic leukemia (ALL). But we need better information about which patients will develop Cytokine Release Syndrome (CRS)--the most common severe toxicity that follows such treatment.

David T. Teachey, Simon F. Lacey, Pamela A. Shaw, J. Joseph Melenhorst, Shannon L. Maude, Noelle Frey, Edward Pequignot, Vanessa E. Gonzalez, Fang Chen, Jeffrey Finklestein, David M. Barrett, Scott L. Weiss, Julie C. Fitzgerald, Robert A. Berg, Richard Aplenc, Colleen Callahan, Susan R. Rheingold, Zhaohui Zheng, Stefan Rose-John, Jason C. White, Farzana Nazimuddin, Gerald Wertheim, Bruce L. Levine, Carl H. June, David L. Porter and Stephan A. Grupp

Brain scans with bar charts

Neuropsychiatric disorders increasingly are conceptualized as disorders of brain development. The authors' new approach can help us to chart normal cortical development and new biomarkers of psychopathology, as well as to understand differences between adolescent males and females.

Simon N. Vandekar, Russell T. Shinohara, Armin Raznahan, Ryan D. Hopson, David R. Roalf,
Kosha Ruparel, Ruben C. Gur, Raquel E. Gur, Theodore D. Satterthwaite

person's arm with tourniquet

TB is the No. 1 killer of HIV+ patients in resource-limited countries, and those with advanced HIV are at especially high risk. But does proactive treatment with an empiric, multi-drug TB regimen help them any better than does screening and simple isoniazid treatment?

Mina C Hosseinipour, MD; Gregory P Bisson, MD; Sachiko Miyahara, PhD; Xin Sun, MS; Agnes Moses, MMED; Cynthia Riviere, MD; Fredrick K Kirui, MMED; Sharlaa Badal-Faesen, MBBCh; David Lagat, MBChB; Mulinda Nyirenda, MMED; Kogieleum Naidoo, MBChB; James Hakim, FRCP; Peter Mugyenyi, MBChB; German Henostroza, MD; Paul D Leger, MD; Javier R Lama, MD; Lerato Mohapi, MBBCh; Jorge Alave, MD; Vidya Mave, MD; Valdilea G Veloso, MD; Sandy Pillay, MBChB; Nagalingeswaran Kumarasamy, PhD; Jing Bao, MD; Evelyn Hogg, BA; Lynne Jones, MT ASCP; Andrew Zolopa, MD; Johnstone Kumwenda, MBChB; Amita Gupta, MD, for the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team


Early-life antibiotic exposure has been associated with increased obesity in animal models. But studies of the association between infant antibiotics and childhood weight gain have reported inconsistent results. This large-scale study offers a persuasive answer.

Jeffrey S. Gerber, MD, PhD; Matthew Bryan, PhD; Rachael K. Ross, MPH; et al

Illustration of testosterone molecule

Following a recommendation by the Institute of Medicine, the authors sought to garner reliable evidence regarding the beneficial effects and the safety of testosterone—a therapy that's widely used in older men who show low levels on a serum testosterone test.

Peter J. Snyder, M.D., Shalender Bhasin, M.D., Glenn R. Cunningham, M.D., Alvin M. Matsumoto, M.D., Alisa J. Stephens-Shields, PhD, Jane A. Cauley, Dr.P.H., Thomas M. Gill, M.D., Elizabeth Barrett-Connor, M.D., Ronald S. Swerdloff, M.D., Christina Wang, M.D., Kristine E. Ensrud, M.D., M.P.H., Cora E. Lewis, M.D., M.S.P.H., John T. Farrar, M.D., PhD, David Cella, Ph.D., Raymond C. Rosen, Ph.D., Marco Pahor, M.D., Jill P. Crandall, M.D., Mark E. Molitch, M.D., Denise Cifelli, M.S., Darlene Dougar, M.P.H., Laura Fluharty, M.P.H., Susan M. Resnick, Ph.D., Thomas W. Storer, Ph.D., Stephen Anton, Ph.D., Shehzad Basaria, M.D., Susan J. Diem, M.D., M.P.H., Xiaoling Hou, M.S., Emile R. Mohler, III, M.D., J. Kellogg Parsons, M.D., M.H.S., Nanette K. Wenger, M.D., Bret Zeldow, M.S., J. Richard Landis, PhD, and Susan S. Ellenberg, PhD, for the Testosterone Trials Investigators

person holding cooler next to stretcher

The authors shed light on a previously unidentified source of disparity in liver transplantation: transplant centers vary widely in the organs they accept, leaving many of the sickest patients to die while awaiting a life-saving organ.

David S. Goldberg, Benjamin FrenchJames D. Lewis, Frank I. Scott, Ronac Mamtani, Richard Gilroy, Scott D. Halpern, Peter L. Abt

woman viewing mammogram results

This study expanded our understanding on the subject by looking not just at screening mammograms but also at subsequent diagnostic mammography and mammography-guided biopsy. Its unique perspective contributed evidence for the U.S. Preventive Services Task Force’s 2016 breast cancer screening guideline update.

Diana L. Miglioretti, PhD; Jane Lange, PhD; Jeroen J. van den Broek, MSc; Christoph I. Lee, MD, MSHS; Nicolien T. van Ravesteyn, PhD; Dominique Ritley, MPH; Karla Kerlikowske, MD; Joshua J. Fenton, MD, MPH; Joy Melnikow, MD, MPH; Harry J. de Koning, PhD; Rebecca A. Hubbard, PhD

About the CCEB

How can we answer and anticipate the pressing health issues we face together as a society? At the CCEB we rise to that challenge through research and training in epidemiology and in biostatistics. We solve problems facing patients and populations. READ MORE ABOUT CCEB



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