This course is designed to introduce students to advanced epidemiologic methods through a series of readings and discussions. The course aims to deepen the students' understanding of important concepts and controversies in contemporary epidemiology and to enhance their ability to think critically about empirical epidemiologic research. The course is intended for students who already are familiar with the fundamentals of epidemiology and biostatistics, and who wish to gain an understanding of the complex issues underlying epidemiologic study design and interpretation. Each week, one student will be responsible for leading a portion of the discussion of the assigned readings, in conjunction with a faculty member. Topics include: causal inference; study designs; use of large databases for research; predicting outcomes; and complex sampling methods.