Featured Research

image The impact of opioid withdrawal symptoms on pain outcomes in enriched enrollment randomized withdrawal trials: a mediation meta-analysis of trials submitted to the US Food and Drug Administration

In a recent analysis, CCEB Senior Scholars, along with other Penn researchers, worked together to evaluate the efficacy of opioid treatments for chronic pain and withdrawal symptoms.

 Christopher J Miller, Andrew Conroy, Warren B Bilker, Alisa J Stephens-Shields, John T Farrar
image Advancing Juvenile Spondyloarthritis: Closing Knowledge Gaps with New Axial JSpA Classification Criteria

Throughout epidemiological studies, Juvenile Spondyloarthritis (JSpA) remains an understudied group with gaps between data and clinical trials. Read more.

 Brittney N Newby, Pamela F Weiss
image Training a Smoking Status Probabilistic Model Using Cotinine Levels in a Large Claims Database

Smoking status is an important confounder for many epidemiologic studies, yet it is not well documented in common sources of real-world data, including administrative claims. Read more.

 Dominique Medaglio, Charles E Leonard, Alisa J Stephens Shields, Robert A Schnoll, Robert Gross.
image Promoting Optimal Development: Screening for Mental Health, Emotional, and Behavioral Problems: Clinical Report

Dr. James Guevara’s recent clinical report on mental health, emotional, and behavioral problems (MEB) within children in the United States examines and expands on the recommendations and criteria listed in the 2019 American Academy of Pediatrics. Read more.

 Carol Weitzman, James Guevara, Michelle Curtin, Michelle Macias; AAP Section on Developmental and Behavioral Pediatrics; AAP Council on Early Childhood; AAP Committee on Psychosocial Aspects of Child and Family Health; SOCIETY FOR DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
image Comparing retrospective informant assessments to prospectively collected cognitive measures in the Health and Retirement Study

Using generalized estimating equations, Dr. Hamedani's team compared informant-reported change in memory and daily functioning to prospectively collected delayed word recall and instrumental activities of daily living (iADL) in the 10 years preceding Harmonized Cognitive Assessment Protocol (HCAP). Read more.

 Ali G Hamedani, Dylan Thibault, Katya Rascovsky, Allison W Willis, Kenneth M Langa
image Predictors of successful initiation of buprenorphine in enriched enrollment randomized withdrawal clinical trials in both opioid experienced and naïve participants: a participant-level meta-analysis

No prediction models exist for the success for buprenorphine initiation in opioid-naïve patients or in transition from other opioids in patients treated for chronic pain. Drs Farrar and Bilker and their team set out to create such a prediction model. Read more.

 Andrew Conroy, Warren B Bilker, Christopher J Miller, Charles E Argoff, Russell Bell, Jennifer Haythornthwaite, Jennifer S Gewandter, Ian Gilron, Katherine N Theken, John T Farrar
image Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: Results of three complementary research designs

Researchers from a recent study involving two CCEB Senior Scholars compared the effects to glaucoma treatments, which served as an active neutral comparator. Read more.

 Tat-Thang Vo, Samrat Roy, Ting Ye, Askhan Erterfaie, Thanh Phuong Pham Nguyen, James Flory, Charles E Leonard, Dylan S Small, Sean Hennessey
image Challenging the Continued Usefulness of Social Media Recruitment for Surveys of Hidden Populations of People Who Use Opioids

In this viewpoint paper, we assessed social media recruitment for people who use opioids and described challenges and potential solutions for effective recruitment.

 Elizabeth D Nesoff, MPH, PhD ; Joseph J Palamar, PhD ; Qingyue Li, MSSP ; Wenqian Li, MSSP ; Silvia S Martins, MD, PhD.
image Association of Race and Ethnicity With Healthcare Utilization for Inflammatory Bowel Disease in the United States: A Retrospective Cohort Study

CCEB Senior Scholars collaborated with other experts in a recent study to evaluate the variations in healthcare for IBD patients by race and ethnicity. Read more.

 Abraham Segura, Colleen Brensinger, Virginia Pate, Shazia M Siddique, Lauren Parlett, Andres Hurtado-Lorenzo, Michael David Kappelman, James D Lewis