Centers of Excellence

CPeRT

Center for Pharmacoepidemiology
Research and Training

New Publication: Association between mothers' postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort study, Bethell, et al.

New Publication: Association between mothers' postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort study, Bethell, et al.

Jul 21, 2020

Association between mothers' postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort study

Jennifer Bethell, Mark D Neuman, Brian T Bateman, Karim S Ladha, Andrea Hill, Guohua Li, Duminda N Wijeysundera, Hannah Wunsch 

 

Abstract 

Background: Postoperative opioid prescriptions may be associated with risks of unintentional poisoning and drug diversion in other household members. The objective of this study was to explore the association between mothers' postoperative opioid prescriptions and incidence of opioid-related events in their children (aged 1 to 24 years).

Data and methods: This retrospective cohort study used individually linked administrative health data from Ontario, Canada. A population-based sample of 170,156 opioid-naïve mothers (aged 15 to 64) (see Figure 1) who underwent surgery between 2013 and 2017 in Ontario was linked through birth records to create a cohort of their 283,550 opioid-naïve children (aged 1 to 24). The association between postoperative opioid analgesic prescriptions filled by mothers within seven days of discharge after surgery and opioid-related events (emergency department presentations or inpatient admissions for opioid poisoning, or mental and behavioural disorders attributable to opioid use) in their children within one year of their mother's discharge was assessed.

Results: Overall, 60.4% of the children in the cohort had a mother who filled a postoperative opioid prescription. The incidence of opioid-related events in children in the year after a mother's surgery was low overall (n=36/283,550, 0.01%), but higher among children whose mother filled a postoperative opioid prescription (n=29/171,139, 0.02%, vs. n=7/112,411, 0.01%, p=0.02), including in an analysis adjusting for child's age, mother's age, rural residence, neighbourhood income quintile and mother's Charlson comorbidity index score (adjusted odds ratio, 2.42 [95% confidence interval (CI), 1.05 to 5.54], p=0.04).

Discussion: Postoperative opioid prescriptions for mothers may contribute to opioid-related events in their children. These findings further underscore the importance of safe, effective opioid prescribing, as well as of patient and public education about the use, storage and disposal of these medications.

 

Read Full Artice Here

Share this Content

About CPeRT

Center for Pharmacoepidemiology Research and Training (CPeRT) members are leaders in the development and use of large administrative and medical record databases for studying drug effects. CPeRT is one of the academic partners of the Food and Drug Administration (FDA)-funded Mini-Sentinel Initiative. CPeRT members also edit Pharmacoepidemiology, 5th edition and Textbook of Pharmacoepidemiology.

Directions to CPeRT

8th Floor, Blockley Hall

University of Pennsylvania

423 Guardian Drive

Philadelphia, PA 19104-6021

 

Social Media