"Modeling Metabolic Systems: Tools and Subtleties"
October 20, 2009 @ 3:30 pm - 4:30 pm
Raymond Boston, Ph.D., University of Pennsylvania
Location: BRB - 251
TITLE: Modeling Metabolic Systems: Tools and Subtleties
For over fifty years computer-driven mathematical models have been developed to assist in the understanding of physiological and molecular systems. Particular concerns of these investigations have been helping to locate defective tissue and creating the tools and indices to quantify the level of impairment. Starting in the nineteen fifties models were used to probe the thyroid system and to understand its dependency on iodine, then in the sixties the skeletal system was studied with a view to establishing mechanisms for meeting the healthy calcium needs of bone, and so on for the seventies, eighties etc. In this quest to sharpen our understanding of topical health issues mathematical and statistical methods have been pivotal in the fabrication and standardization of techniques to enhance the practicality of probing and quantifying complex systems.
In this seminar, and in the context of two novel modeling contributions, we will describe some of the methodologies very recently refined for the estimation of insulin secretion, and for the assessment of energy substrate switching, or metabolic elasticity.
Boston RC and PJ Moate: A Novel Minimal Model to describe NEFA kinetics following an intravenous glucose challenge. Am J Physiol Regul, Integr and Comp Physiol. 294: R1140-R1147, January 2008
Boston, RC and PJ. Moate: NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test. Am J Physiol Regul Integr Comp Physiol 295: R395-R403, June 2008
Boston, RC, D Pei, and PJ Moate: A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance test. Metabolism, July, 58(7):891-900 2009