Jeffrey S. Barrett, PhD, FCP
|CCEB Appointment||Associate Scholar, Epidemiology|
|Primary Faculty Appointment||Research Professor, Pediatrics, CHOP, Perelman School of Medicine|
My research is focused on investigating sources of variation in pharmacokinetics and pharmacodynamics applying clinical pharmacologic investigation coupled with modeling and simulation strategies to pursue rational dosing guidance. My group develops pharmacometric approaches to advance PK/PD, medical informatics and disease progression modeling. We have also integrated model-based decision support systems with hospital electronic medical records and pioneered the pediatric knowledgebase development program for the past 6 years. My group is actively involved with creating disease progression models for spinal muscular atrophy (SMA) and pancreatic cancer and his team is developing model-based development approaches for Traditional Chinese Medicine (TCM) and gene therapy.
Skolnik JM, Zhang AY, Barrett JS, Adamson PC. Approaches to clear residual chemotherapeutics from indwelling catheters in children with cancer. Ther Drug Monit 32:741-748, 2010.
Barrett JS, Skolnik JM, Jayaraman B, Patel D, Adamson PC. Discrete event simlulation applied to pediatric phase I oncology designs. Clinical Pharmacology & Therapeutics 84(6): 729-733, 2008.
Barrett JS, Fossler MJ, Cadieu D, Gastonguay MR. Pharmacometrics: A multidisciplinary field to facilitate critical thinking in drug development and translational research settings. J Clin Pharmacol 48:632-649, 2008.
Barrett JS, Mondick JT, Narayan M, Vijayakumar K, Vijayakumar S. Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy. BMC Medical Informatics and Decision Making 8:6, 2008.
Barrett JS, Gupta M, Mondick JT. Model-based drug development applied to oncology. Expert Opin Drug Discov 2(2):185-209, 2007.