Jason Christie, MD, MSCE

Office Location719, Blockley Hall
Office Phone215-573-3209
Emailjchristi@mail.med.upenn.edu

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentAssociate Professor of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman SOM
DBE AppointmentAssociate Professor of Epidemiology

Research Statement

Jason D. Christie, M.D., M.S. is the Section Chief of Medical Critical Care. He is currently Associate Professor of Medicine in the Department of Pulmonary/Critical Care Medicine and Associate Professor of Epidemiology in the Department of Biostatistics and Epidemiology at the University of Pennsylvania. He is a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, and the Director of Clinical Research in the Pulmonary Division. His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury (ALI) in the transplant and non-transplant human populations.

Currently, Dr. Christie has extramural funding to support active research on somatic genetic variation, gene expression, and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations. His research brings together clinicians, basic scientists, epidemiologists, and statisticians to build multidisciplinary studies of acute lung injury research.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study on the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). His research focuses on the role of oxidative stress, coagulation/fibrinolysis, inflammatory and innate immune pathways in primary graft dysfunction. This line of research is funded by multiple R01 grants from NHLBI, focusing on genetic risks, clinical on plasma protein biomarkers as risk factors for primary graft dysfunction. One R01 is in close collaboration with Dr. David Wilkes, and focuses on the role of autoimmunity to type V collagen in primary graft dysfunction pathogenesis.

Dr. Christie is actively involved in sepsis and major trauma research, focusing on acute luing injury. He recently formed a multicenter collaboration, called the Trauma ALI SNP Consortium (TASC) and published the first genome wide genetic association studies of ALI risk and outcomes.

Selected Publications

Critical Care:

Meyer NJ, Feng R, Li M, Zhao Y, Sheu CC, Tejera P, Gallop R, Bellamy S, Rushefski M, Lanken PN, Aplenc R, O'Keefe GE, Wurfel MM, Christiani DC, Christie JD: IL1RN Coding Variant Is Associated with Lower Risk of Acute Respiratory Distress Syndrome and Increased Plasma IL1RA. Am J Respir Crit Care Med, 187(9):950-9 May 2013.

Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova E, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H, and Christie JD: ANGPT2 Genetic Variant Is Associated with Trauma-Associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. Am J Respir Crit Care Med 183: 1344-1353, May 2011. PMCID: PMC3114062.

Mikkelsen ME*, Christie JD*, Lanken PN, Biester RC, Thompson BT, Bellamy SL, Localio AR, Demissie E, Hopkins RO, Angus DC (*contributed equally as first authors): The ARDS cognitive outcomes study (ACOS): Long-term neuropsychological function in acute lung injury survivors. Am J Respir Crit Care Med 185(12): 1307-15, Jun 2012.

Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay MA, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc RA, Maloney JP, Hakonarson H for the Trauma ALI SNP Consortium (TASC) Investigators: Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma. PLoS One 7(1): e28268, Jan 2012. PMCID: PMC3266233

Shah CV, Lanken P, Localio AR, Gallop R, Bellamy S, Ma SF, Flores C, Kahn J, Finkel B, Fuchs B, Garcia JGN, Christie JD: An alternative method of acute lung injury classification for use in observational studies. Chest 138(5): 1054-1061, Nov 2010. PMCID: PMC2972624

Lung Transplantation:

Diamond JM, Meyer NJ, Feng R, Rushefski M, Lederer DJ, Kawut SM, Lee JC, Cantu E, Shah R, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Arcasoy S, Shah PD, Belperio JA, Wilkes D, Ware LB, Palmer SM and Christie JD for the Lung Transplant Outcomes Group: Variation in PTX3 is associated with primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med 186(6): 546-552, Sep 2012

Diamond JM, Kawut SM, Lederer DJ, Ahya VN, Kohl B, Sonett J, Palmer SM, Crespo M, Wille KM, Lama V, Shah PD, Orens J, Bhorade S, Weinacker A, Demissie1 E, Bellamy S, Christie JD, Ware LB for the Lung Transplant Outcomes Group. Elevated Plasma Clara Cell Secretory Protein Concentration is Associated with High Grade Primary Graft Dysfunction. American Journal of Transplantation. 11(3): 561-567, Mar 2011. PMCID: PMC3206646, PMID: 21883907

Diamond JM, Lederer DJ, Kawut SM, Lee J, Ahya VN, Bellamy S, Palmer SM, Lama VN, Bhorade S, Crespo M, Demissie E, Sonett J, Wille K, Orens J, Weinacker A, Weill D, Kohl BA, Deutschman C, Arcasoy S, Shah AS, Shah PD, Belperio JA, Wilkes D, Reynolds JM, Ware LB, Christie JD for the Lung Transplant Outcomes Group: Elevated Plasma Long Pentraxin-3 Concentration and Primary Graft Dysfunction after Lung Transplantation for Idiopathic Pulmonary Fibrosis. American Journal of Transplantation 11(11): 2517-22, Nov 2011. PMCID: PMC3206646, PMID: 21883907

Lederer DJ, Kawut SM, Wickersham N, Winterbottom C, Bhorade S, Palmer SM, Lee J, Diamond JM, Wille KM, Weinacker A, Lama VN, Crespo M, Orens JB, Sonett JR, Arcasoy SM, Ware LB, and Christie JD for the Lung Transplant Outcomes Group: Obesity and Primary Graft Dysfunction After Lung Transplantation: The LTOG Obesity Study. Am J Respir Crit Care Med 184(9): 1055-61. Nov 2011. PMCID: PMC3208644, PMID: 21799077

Shah RJ, Bellamy SL, Localio AR, Wickersham N, Diamond JM, Weinacker A, Lama VN, Bhorade S, Belperio JA, Crespo M, Demissie EJ, Kawut SM, Wille KM, Lederer DJ, Lee JC, Palmer SM, Orens J, Reynolds J, Shah A, Wilkes DS, Ware LB*, Christie JD* (*contributed equally): A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. J Heart Lung Transplant 31(9): 942-9, Sep 2012

Thabut G, Christie JD, Ravaud P, Castier Y, Dauriat G, Jebrak G, Fournier M, Lesèche G, Porcher R, Mal H: Survival after bilateral versus single lung transplantation for patients with idiopathic pulmonary fibrosis. Annals of Internal Medicine 151: 767-774, Dec 2009

Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I, Brand DB, Burlingham W, Gopalakrishnan B, Greenspan DS, David S. Wilkes*, Christie JD* (Co-senior authors due to equal contributions): Anti-type V Collagen Humoral Immunity in Lung Transplant Primary Graft Dysfunction. Journal of Immunology 181: 5738-5747, October 2008.

Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S, for the Lung Transplant Outcomes Group. Association Of Protein C And Type-1 Plasminogen Activator Inhibitor With Primary Graft Dysfunction. Am J Respir Crit Care Med 2007 Jan 1;175(1):69-74.



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